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Jon Udell: JavaScript, Perl, Python, .NET. Could the same principles bring this Perl/Python research to fruition?
Depends on what your goals are. As you so aptly put it in your thread on Ruby (the language), "To be free to innovate, which Ruby indisputably does in some important ways, a language has to carry a lot of baggage. Conversely a language that travels light, acquiring everything from its environment -- like any .NET language -- has limited scope for innovation."
This picture is likely to change dramatically when Parrot is ready.